Figure 7.

Correlation of events along the lytic cascade. (A) Schematic timelines of individual cells along the lytic cascade from the time of induction at t₀=0, through the onset time of pR′-tR′ expression, t_pR′-tR′, and ending in the time of lysis, t_lysis, assuming uniform time dilation from cell to cell, yielding the schematic correlation between the intervals Δt=t_lysis−t_pR′-tR′ (green) and t_pR′-tR′−t₀ (red) shown in (B). (C) Individual cell timelines assuming the execution of the cascade is affected by random fluctuations in timing of the various stages, in which case Δt and t_pR′-tR′ vary independently, yielding the schematic correlation shown in (D). (E) Measured intervals Δt in individual cells completing the lytic cascade as a function of t_pR′-tR′. A correlation analysis yields a P-value equal to 0.59, suggesting that both quantities are not correlated.