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. 2007 Jan 10;14(3):304–311. doi: 10.1128/CVI.00363-06

FIG. 4.

FIG. 4.

A single dose of IC.BVP22 DNA vaccine primes T- and B-lymphocyte responses. (A) F2-5-specific IFN-γ+ CD4+ responses. An asterisk denotes statistically significant differences between the IC.BVP22 group mean and both the BVP22R and the VR-1055 vector group means, whereas a dagger denotes a lack of a statistically significant difference between the BVP22R and the VR-1055 vector group means. (B) F2-5-specific CD4+ T-cell proliferation. The double dagger denotes statistically significant differences between the IC.BVP22 vector group mean and both the BVP22R and the VR-1055 vector group means, whereas double vertical lines denote a lack of a statistically significant difference between the BVP22R and the VR-1055 vector group means. All responses were measured 11 days following a single DNA vaccine immunization. The bars represent group means, and the arrows point to the responses detected in calves 3937 and 3959.