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Two PtdIns 3-kinase complexes in yeast. (a) Both complexes share Vps15, Vps30/Atg6 and Vps34. Complex I has Atg14 and functions in autophagy and the Cvt pathway. Complex II contains Vps38 and is involved in the CPY and Mvb pathways. (b) It is hypothesized that complex I might generate PtdIns(3)P for autophagy and the Cvt pathway at the PAS. The Atg20-Atg24 complex, Atg18, Atg21 and Atg27 are recruited to the PAS through their association with PtdIns(3)P
