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. Author manuscript; available in PMC: 2007 Mar 20.
Published in final edited form as: Cell Death Differ. 2005 Nov;12(Suppl 2):1542–1552. doi: 10.1038/sj.cdd.4401765

Figure 6.

Figure 6

Recycling of Atg9 and Atg23. Atg9 and Atg23 localize at the PAS and at multiple peripheral punctate structures (shown to be the mitochondria for Atg9). Retrieval of the integral membrane protein Atg9 from the PAS involves the Atg1-Atg13 complex, Atg2, and Atg18. The PtdIns 3-kinase complex I is proposed to generate PtdIns(3)P at the PAS, and Atg18 is likely localized to the PAS through its association with this phosphoinositide. The Atg1-Atg13 complex induces the interaction of Atg2, Atg9 and Atg18. Finally, this ternary complex allows Atg9 retrieval from the PAS. Atg23 is a peripheral membrane protein. It is not known whether Atg23 is recruited to the PAS from a cytosolic or membrane-associated pool. In contrast to Atg9, a high level of Atg1 kinase activity is needed to mediate the retrieval of Atg23 from the PAS