Figure 2. Gender- and strain-specific expression of enzymatic activities involved in mouse renal AA metabolism.

(A) Representative RP-HPLC chromatogram of AA metabolites produced by renal microsomes isolated from male and female NMRI mice. (B–D) Renal AA hydroxylase, AA epoxygenase, and soluble epoxide hydrolase activities of male and female NMRI, FVB/N, 129 Sv/J, Balb/c and C57BL/6. Results shown are means±S.E.M. (n=6 in each group). Significant differences (P<0.05) between the groups are marked as follows: *, compared with other gender of the same strain; #, compared with other males; +, compared with FVB/N and C57BL/6; §, compared with Balb/c.