Figure 3. Effect of 5α-DHT on Cyp4a12a expression and renal microsomal 20-HETE production in male NMRI and C57BL/6.
(A, B) Cyp4a12a mRNA levels in total kidney and renal arterioles; (C) renal Cyp4a12 protein levels; (D) renal microsomal AA hydroxylase activities. Results are means±S.E.M. (n=6 each). Significant differences (P<0.05) between the groups are marked as follows: *, compared with untreated C57BL/6; #, compared with untreated NMRI; +, compared with testosterone-treated C57BL/6.