. Author manuscript; available in PMC: 2008 Jan 1.

Published in final edited form as: Biochem Pharmacol. 2006 Sep 14;73(1):147–154. doi: 10.1016/j.bcp.2006.09.008

Table 3.

IC₅₀ values of various SSRIs towards human PMAT versus estimated free drug concentrations in human brain

SSRI	IC₅₀ towards PMAT (μM)	stimated brain free drug concentration^* (μM)
Fluoxetine	28.39 ± 7.22	0.13-0.44
Paroxetine	22.46 ± 5.68	0.02-1.32
Citalopram	116.67 ± 13.09	0.18-1.33
Fluvoxamine	11.00 ± 1.88	0.14-3.73
Sertraline	13.54 ± 1.67	0.009-0.087

values are calculated as steady state plasma concentrations of total drug times plasma unbound fraction using data from [22, 23], assuming that unbound brain concentrations of SSRIs approximate their unbound plasma concentrations [32].