Table 3.

Summary of Clinical Data on BDNF Expression and Effects of Hormone Replacement Therapy in Specific Neurodegenerative Diseases

Disease	BDNF Regulation	Ref(s)	Hormone Replacement Therapy	Ref(s)
Alzheimer’s	↓protein expression	[22,34,46,80,89]	↓risk for AD	[92,125,146]
Disease	↓mRNA expression	[50,87,98]	↑risk for dementia	[33,114]
	BDNF present in cells surrounding plaques	[34]	no benefit	[86]
Parkinson’s	↓protein expression	[54,84,94]	↓risk for PD	[24]
Disease			↓in PD symptoms	[9,108]
			↓in PD symptoms	[90]
			no benefit	[121]
Multiple Sclerosis	↑protein expression w/increased demyelination	[63,119]	↑MS symptoms	[4,99]
	↑mRNA expression	[39]	↑risk for MS	[128]