FIG. 1.

AlpA belongs to the third group of the Dis1/XMAP215 family. (A) Two TOG domains, eight HEAT repeats, and a coiled-coil region were identified, which are common to all class three members, including S. pombe Alp14 and Dis1, which is the Dis1/XMAP215 family-founding protein, and S. cerevisiae Stu2. Members of the first group include human ch-TOG, Xenopus XMAP215, Drosophila melanogaster Msps, D. discoideum DdCP224, and Arabidopsis thaliana MOR1. So far, there is only one known group two member, namely ZYG-9 of Caenorhabditis elegans. (B) Phylogenetic analysis of S. pombe Alp14 (Sp) homologues with S. cerevisiae (Sc), A. nidulans (An), A. fumigatus (Af), and A. oryzae (Ao). Accession numbers are indicated.