Fig. 2.

Expression of Cbx7 in the murine lymphoid compartment causes mature T cell lymphomas. (A) Kaplan–Meier curve showing tumor-free survival. Mice reconstituted with HSCs infected as indicated were monitored for lymphoma onset and illness until they reached a terminal stage and were killed. The data are presented in a Kaplan–Meier format, showing the percentage of mouse survival at various times after reconstitution. (B) Characterization of Cbx7-overexpressing lymphomas. Representative pictures are shown. (C) Western blot of Cbx7 overexpressing lymphomas showing exogenously expressed Cbx7 and endogenous c-Myc levels. β-Actin is used as a loading control. MEFs of the indicated genotypes and a lymphoma arising in a vav-MYC transgenic mouse were used as controls.