TABLE 1.
Fluconazole and voriconazole MIC distribution profiles for 13,338 clinical isolates of Candida spp. tested by Clinical and Laboratory Standards Institute-recommended broth microdilution methodsa
| Species (no. of isolates tested) | Antifungal agent | No. of isolates at MIC (μg/ml) of:
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.007 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | ||
| C. albicans (7,725) | Fluconazole | 2,121 | 4,387 | 751 | 210 | 104 | 33 | 32 | 31 | 7 | 49 | ||||
| Voriconazole | 5,624 | 1,417 | 372 | 181 | 39 | 38 | 17 | 12 | 10 | 1 | 14 | ||||
| C. glabrata (1,966) | Fluconazole | 1 | 4 | 6 | 18 | 164 | 477 | 547 | 491 | 77 | 181 | ||||
| Voriconazole | 3 | 5 | 29 | 237 | 584 | 584 | 223 | 139 | 89 | 50 | 21 | 2 | |||
| C. parapsilosis (1,623) | Fluconazole | 4 | 163 | 636 | 479 | 213 | 55 | 27 | 30 | 8 | 8 | ||||
| Voriconazole | 265 | 589 | 409 | 219 | 70 | 47 | 12 | 7 | 4 | 1 | |||||
| C. tropicalis (1,253) | Fluconazole | 21 | 240 | 390 | 322 | 202 | 36 | 14 | 7 | 2 | 19 | ||||
| Voriconazole | 120 | 203 | 382 | 386 | 100 | 27 | 8 | 6 | 3 | 4 | 9 | 5 | |||
| C. krusei (312) | Fluconazole | 2 | 7 | 31 | 146 | 126 | |||||||||
| Voriconazole | 1 | 28 | 137 | 126 | 18 | 1 | 1 | ||||||||
| C. lusitaniae (134) | Fluconazole | 5 | 44 | 43 | 22 | 11 | 3 | 2 | 1 | 2 | 1 | ||||
| Voriconazole | 77 | 36 | 8 | 7 | 2 | 2 | 1 | 1 | |||||||
| C. dubliniensis (103) | Fluconazole | 46 | 39 | 4 | 1 | 4 | 2 | 4 | 3 | ||||||
| Voriconazole | 60 | 24 | 8 | 1 | 2 | 4 | 2 | 2 | |||||||
| C. guilliermondii (92) | Fluconazole | 1 | 1 | 3 | 32 | 31 | 15 | 5 | 1 | 3 | |||||
| Voriconazole | 2 | 3 | 14 | 36 | 18 | 9 | 7 | 2 | 1 | ||||||
| C. pelliculosa (34) | Fluconazole | 6 | 21 | 7 | |||||||||||
| Voriconazole | 1 | 20 | 11 | 2 | |||||||||||
| C. kefyr (33) | Fluconazole | 4 | 16 | 11 | 2 | ||||||||||
| Voriconazole | 18 | 12 | 3 | ||||||||||||
| C. famata (19) | Fluconazole | 1 | 3 | 3 | 1 | 4 | 2 | 5 | |||||||
| Voriconazole | 2 | 3 | 2 | 2 | 2 | 5 | 3 | ||||||||
| C. rugosa (19) | Fluconazole | 13 | 2 | 4 | |||||||||||
| Voriconazole | 10 | 1 | 5 | 1 | 2 | ||||||||||
| Candida spp.b (25) | Fluconazole | 1 | 1 | 3 | 2 | 2 | 7 | 2 | 1 | 6 | |||||
| Voriconazole | 3 | 2 | 4 | 2 | 7 | 1 | 3 | 1 | 1 | 1 | |||||
| Total (13,338) | Fluconazole | 2,203 | 4,896 | 1,849 | 1,064 | 740 | 674 | 661 | 607 | 248 | 396 | ||||
| Voriconazole | 6,174 | 2,300 | 1,232 | 1,079 | 874 | 869 | 404 | 183 | 110 | 57 | 31 | 25 | |||
a
Broth microdilution MICs determined in accordance with CLSI M27-A2.
b
Includes C. lipolytica (7 isolates), C. zeylanoides (5 isolates), C. inconspicua (3 isolates), C. lambica (2 isolates), C. sake (2 isolates), C. norvegensis (1 isolate), and Candida spp. not otherwise identified (5 isolates).