TABLE 3.
Frequency distribution of genetic groups, Beijing/W lineage, age, gender, race/ethnicity, HIV serostatus, and plcD genotype between the two sites of disease assessed by bivariate χ2 test or Fisher's exact test
| Variable | No. (%) positive for:
|
P value | |
|---|---|---|---|
| TTBa (n = 598) | ETTBb (n = 78) | ||
| Genetic group | 0.1685 | ||
| 2 | 394 (65.9) | 44 (56.4) | |
| 1 | 52 (8.7) | 11 (14.1) | |
| 3 | 152 (25.4) | 23 (29.5) | |
| Beijing/W lineagec | 0.0617 | ||
| No | 567 (95.1) | 70 (89.7) | |
| Yes | 29 (4.9) | 8 (10.3) | |
| Age (yr) | 0.3217 | ||
| <65 | 294 (49.2) | 43 (55.1) | |
| ≤65 | 304 (50.8) | 35 (44.9) | |
| Gender | 0.0013 | ||
| Male | 395 (66.1) | 37 (47.4) | |
| Female | 203 (33.9) | 41 (52.6) | |
| Race/ethnicity | 0.0013 | ||
| Non-Hispanic White | 350 (58.5) | 29 (37.2) | |
| Non-Hispanic Black | 193 (32.3) | 40 (51.3) | |
| Other | 55 (9.2) | 9 (11.5) | |
| HIV serostatus | 0.0004 | ||
| Negative | 276 (46.2) | 36 (16.2) | |
| Positive | 16 (2.7) | 9 (11.5) | |
| Unknown | 306 (51.2) | 33 (42.3) | |
| plcD genotype | 0.0293 | ||
| plcD wild type | 401 (67.1) | 44 (56.4) | |
| plcD mutation | 29 (4.8) | 9 (11.5) | |
| plcD and adjacent gene mutation | 168 (28.1) | 25 (32.1) | |
a
TTB, thoracic TB.
b
ETTB, extrathoracic TB.
c
Spoligotyping results were not available for two isolates, and, therefore, only 674 of the 676 isolates/patients were included in this analysis.