TABLE 2.
Dalbavancin activity compared to those of seven other agents when tested against 2,490 gram-positive coccus isolates in 52 laboratories by Etest and disk diffusion methods (United States, 2005 and 2006)
| Organism group (no. tested) | Antimicrobial agent | % of strains
|
|
|---|---|---|---|
| Susceptiblea | Resistantb | ||
| S. aureus | |||
| Oxacillin-resistant (1,009) | Dalbavancin | 100.0 | - |
| Vancomycin | 99.8 | 0.0 | |
| Erythromycin | 5.4 | 94.1 | |
| Clindamycin | 55.2 | 41.7 | |
| Levofloxacin | 27.7 | 70.3 | |
| Gentamicin | 92.0 | 7.9 | |
| Tetracycline | 91.8 | 8.0 | |
| Linezolid | 99.7 | - | |
| Oxacillin-susceptible (762) | Dalbavancin | 100.0 | - |
| Vancomycin | 100.0 | 0.0 | |
| Erythromycin | 65.8 | 30.6 | |
| Clindamycin | 92.8 | 5.8 | |
| Levofloxacin | 91.1 | 7.6 | |
| Gentamicin | 98.7 | 1.3 | |
| Tetracycline | 95.1 | 4.4 | |
| Linezolid | 99.9 | - | |
| Coagulase-negative staphylococcic | |||
| Oxacillin-resistant (182) | Dalbavancin | 100.0 | - |
| Vancomycin | 100.0 | 0.0 | |
| Erythromycin | 18.6 | 81.4 | |
| Clindamycin | 41.5 | 53.6 | |
| Levofloxacin | 31.9 | 64.3 | |
| Gentamicin | 58.2 | 35.6 | |
| Tetracycline | 82.4 | 16.4 | |
| Linezolid | 100.0 | - | |
| Oxacillin-susceptible (58) | Dalbavancin | 100.0 | - |
| Vancomycin | 100.0 | 0.0 | |
| Erythromycin | 45.2 | 51.6 | |
| Clindamycin | 79.0 | 21.0 | |
| Levofloxacin | 82.3 | 9.7 | |
| Gentamicin | 95.0 | 5.0 | |
| Tetracycline | 95.0 | 5.0 | |
| Linezolid | 98.4 | - | |
| β-Hemolytic streptococci | Dalbavancin | 100.0 | - |
| (479)d | Vancomycin | 100.0 | 0.0 |
| Penicillin | 98.3 | - | |
| Ceftriaxone | 98.9 | - | |
| Erythromycin | 76.9 | 20.2 | |
| Clindamycin | 87.7 | 6.0 | |
| Levofloxacin | 98.7 | 0.2 | |
| Linezolid | 99.8 | - | |
Susceptibility criteria of the CLSI (M100-S16, 2006) were used where available (7). For dalbavancin, the sponsor-proposed susceptible-only breakpoints of ≤1 μg/ml (staphylococci) and ≤2 μg/ml (streptococci) were used for comparisons with vancomycin, with both drugs tested by Etest (AB BIODISK).
-, no resistance breakpoint criteria have been recommended.
CoNS included S. capitis (3 strains), S. epidermidis (59 strains), S. haemolyticus (4 strains), S. hominis (4 strains), S. lugdunensis (4 strains), S. saprophyticus (1 strain), S. simulans (2 strains), S. warneri (4 strains), and CoNS unidentified to the species level (159 strains).
β-Hemolytic serotypes of streptococci were group A (302 strains), group B (101 strains), group C (26 strains), group F (eight strains), and group G (42 strains).