TABLE 5.
Population survey data for fully concordant samplesa for P. falciparum infection among Plasmodium species and dhps, dhfr, and pfcrt diagnostic assays
| dhps haplotype | pfcrt haplotypeb | No. of samples with the indicated dhps and pfcrt haplotypes and the following dhfr haplotype:
|
||||||
|---|---|---|---|---|---|---|---|---|
| NCSI | NCNI | NCTI | NRNI | Mixed | None | Total | ||
| SAKAA | CVMNK | 21 | 4 | 27 | 9 | 61 | ||
| SVMNT | 88 | 6 | 1 | 205 | 69 | 369 | ||
| Mixed | 2 | 7 | 11 | 20 | ||||
| None | 0 | |||||||
| Total | 111 | 10 | 1 | 239 | 89 | 0 | 450 | |
| Mixed-haplotype infectionsc | CVMNK | 0 | ||||||
| SVMNT | 2 | 2 | ||||||
| Mixed | 0 | |||||||
| None | 0 | |||||||
| Total | 0 | 0 | 0 | 2 | 0 | 0 | 2 | |
| None | CVMNK | 0 | ||||||
| SVMNT | 0 | |||||||
| Mixed | 0 | |||||||
| None | 468 | 468 | ||||||
| Total | 0 | 0 | 0 | 0 | 0 | 468 | 468 | |
Samples were judged fully concordant if the Plasmodium species assay and the P. falciparum dhps, dhfr, and pfcrt assays were all positive or all negative. These include the 921 samples identified here (450 with the dhps SAKAA allele, 2 with dhps mixed-haplotype infections, 468 with no dhps allele, and 1 carrying pfcrt CVMNK, dhfr NCSI, and dhps SGKAA).
The CVIET pfcrt haplotype was not observed in the samples screened for this study.
Two P. falciparum infections were characterized by parasite strains carrying both dhps SAKAA and SGKAA alleles.