Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Construction of a designer receptor. Native hM3 receptor responds to the natural hormone (Ach) but does not respond to CNO (Upper). This receptor is matured through saturation mutagenesis to result in a designer receptor (Lower), which responds only to the designer drug (CNO) and is impervious to the natural hormone.
