Table 1.
Patient no. | Age, yr | Sex | Time from diagnosis | β cell function | Enteroviral infection of β cells | β cell destruction | Insulitis |
---|---|---|---|---|---|---|---|
1 | 26 | F | —* | Impaired | Yes | No | Minor; dominated by NK cells; no evidence for autoreactive T cells |
2 | 19 | M | 9 months | Partially lost | Yes | No | Minor; dominated by NK cells; no evidence for autoreactive T cells |
3 | 15 | F | 1 week | Lost | Yes | Limited | Minor; dominated by NK cells; no evidence for autoreactive T cells |
4 | 14 | F | 8 months | Lost | No | Yes | Moderate T cell infiltrate; no NK cells |
5 | 5 | M | 1 week | Lost | No | Yes | Moderate T cell infiltrate; no NK cells |
6 | 4 | F | 1 week | Lost | No | Yes | Moderate T cell infiltrate; no NK cells |
M, male; F, female.
*Patient 1 was a recipient of a whole pancreas graft, which was removed after 38 months because of recurrent urinary tract infections.