TABLE 2.
Case-control studies of selenium and coronary heart disease (CHD)1
| Selenium concentration2 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Study, year | Country | Percentage of men among control subjects | Mean age of control subjects | Type of control subjects | Source of case subjects | Outcomes | No. of case subjects/control subjects | Selenium assessment (technique) | Case subjects | Control subjects |
| % | y | |||||||||
| Oster, 1986 (38) | Germany | 100 | 52 | University employees | University health care center | AMI incidence | 49/41 | Serum (AAS) | 56.0 ± 15.03 | 78.0 ± 11.0 |
| Auzepy, 1987 (40) | France | 60 | 34 | Nursing and medical staff | Hospital | AMI incidence | 31/48 | Serum (AAS) | 73.6 ± 13.0 | 84.7 ± 12.4 |
| Salonen, 1988 (41) | Finland | 100 | 54 | Kuopio Ischemic Heart Disease Study | Kuopio Ischemic Heart Disease Study | CHD prevalence | 175/449 | Serum (AAS) | 81.5 ± 19.2 | 85.0 ± 21.6 |
| Kok, 1989 (42) | Netherlands | 70 | 59 | General population | Hospital | AMI incidence | 84/84 | Plasma | 100.8 ± 27.5 | 106.8 ± 23.8 |
| Erythrocytes | 0.54 ± 0.094 | 0.59 ± 0.184 | ||||||||
| Toenail (NAA) | 0.70 ± 0.185 | 0.78 ± 0.185 | ||||||||
| Beaglehole, 1990 (52) | New Zealand | 60 | 52 | General population | Monica Project Registry | AMI incidence | 252/838 | Whole blood (fluorimetry) | 82.7 ± 20.2 | 88.2 ± 20.7 |
| Thiele, 1995 (43) | Germany | NR | NR | Healthy blood donors | Hospital | AMI incidence | 83/62 | Serum (AAS) | 71.0 ± 13.4 | 78.9 ± 13.4 |
| Whole blood | 86.8 ± 15.8 | 105.8 ± 13.4 | ||||||||
| Kardinaal, 1997 (53) | 8 European countries and Israel | 100 | 53 | General population and clinic based | Coronary unit | AMI incidence | 683/729 | Toenail (NAA) | 0.55 ± 0.49–0.695,6 | 0.59 ± 0.49–0.725,6 |
| Coudray, 1997 (44) | France | 40 | 65 | General population | Surveys | AMI prevalence | 36/498 | Plasma (AAS) | 88.4 ± 16.6 | 85.2 ± 15.0 |
| Navarro- Alarcon, 1999 (45) | Spain | NR | NR | NR | Hospital | CHD prevalence | 50/130 | Serum (AAS) | 55.5 ± 16.7 | 74.9 ± 27.3 |
| Bor, 1999 (46) | Turkey | 83 | 51 | NR | Emergency room | AMI incidente | 27/24 | Plasma | 63.7 ± 12 | 82.2 ± 14.6 |
| Erythrocytes (fluorimetry) | 0.48 ± 0.044 | 0.51 ± 0.034 | ||||||||
| Zachara, 2001 (47) | Poland | 62 | 57 | NR | Coronary unit | AMI incidente | 49/58 | Plasma | 53.8 ± 18.3 | 52.5 ± 13.6 |
| Whole blood (fluorimetry) | 71.4 ± 18.2 | 73.1 ± 18.0 | ||||||||
1
AMI, acute myocardial infarction; AAS, atomic absorption spectroscopy; NAA, neutron activation analysis.
2
Measured in μg/L, unless otherwise specified.
3
± SD (all such values).
4
Measured in μg/g hemoglobin.
5
Measured in μg/g.
6
Median (25th and 75th percentiles).