. Author manuscript; available in PMC: 2007 Mar 21.

Published in final edited form as: Bioorg Med Chem. 2005 Sep 1;13(17):5145–5153. doi: 10.1016/j.bmc.2005.05.051

Table 1.

In vitro antiviral activity and cytotoxicity of cyclic D,L-α-peptides.

#	sequence	IC₅₀(μM)^a ^b	LD₅₀(μM)^b
1	c[SHKRKWLW]	5	57
2	c[AHKRKWLW]	8	54
3	c[SAKRKWLW]	13	70
4	c[SHARKWLW]	19	>100
5	c[SHKAKWLW]	7	65
6	c[SHKRAWLW]	6	43
7	c[SHKRKALW]	>30	>100
8	c[SHKRKWAW]	17	100
9	c[SHKRKWLA]	>30	>100
10	c[SHKRKWLW]	7	63
11	c[WLWKRKHS]	5	35

Inhibition of Adenovirus (Ad-5) infections.

HeLa cells were used in both assays.