Figure 7.

Impairment of motor neuron function and axonal transport by dAlc expression in Drosophila. (Upper panels) Larval movement. Movement of elav-GAL4/+ (upper) and elav-GAL4/UAS-dAlc (lower) third instar larvae. Numbers indicate time. See Supplementary Movie 7, in Sup_8.mov. (Lower panels) Aggregation of APPL-containing vesicles by dAlc expression. Immunostaining of axons from elav-GAL4/+ (upper) and elav-GAL4/UAS-dAlc (lower) third instar larvae. Larval segmental nerve axons were stained with antibodies against a synaptic vesicle marker protein (CSP) and APPL. Merged signals are shown in the panels on the right.