Figure 4.

Regulated expression of ADAMTS-1 in preovulatory follicles. In situ hybridization with a radiolabeled antisense probe showed undetectable ADAMTS-1 expression in ovaries of PMSG-treated PR+/− and PRKO mice. In response to hCG, ADAMTS-1 expression was induced in granulosa cells of the large, ovulating follicles of PR+/− mice (black arrows) but not in similar large follicles of PRKO mice (red arrows). ADAMTS-1 expression in ovulating follicles was transient and had decreased in PR+/− granulosa cells by 16 h after hCG.