Table 1.

Major Pathological Findings in Various Organs and Tissue

Organs/tissue	Pathology	Number of cases	References
Respiratory tract	Diffuse alveolar damage with varying degrees of acute exudative features including edema and hyaline membranes, organization, and fibrosis. Macrophagic or mixed cellular infiltration, multinuclear giant cells, atypical reactive pneumocytes, and vascular injury. Positive in situ hybridization signals in pneumocytes, lymphocytes, and macrophages	63	12,13,14,15,16, 18,19,20,21,22,23
Spleen and lymph nodes	Lymphocyte depletion in spleen and lymph nodes with architectural disruption. Splenic white pulp atrophy. Positive in situ hybridization signals in immune cells	25	11,12,13, 15,16,17, 27
Digestive tract	Intestines: no obvious pathological changes/ nonspecific changes. Depletion of mucosal lymphoid tissue. Positive in situ hybridization signals in mucosal epithelial cells	19	12, 13, 39, 46
	Liver: no specific pathological changes. In some cases, necrosis and evidence of apoptosis	20	9, 12, 13, 17, 39, 48
Urogenital tract	Kidneys: acute tubular necrosis, in varying degrees and other nonspecific features. Positive in situ hybridization signals in the epithelial cells of the distal tubules	21	12, 13, 15, 17, 43, 44
Central nervous system	Edema and degeneration of neurons, several neurons in situ hybridization-positive	12	12, 15, 42
Bone marrow	In some cases, reactive hemophagocytosis	9	9, 12, 25
Skeletal Muscles	Myofiber necrosis and atrophy, few regenerative myofibers	13	12, 44, 46
Adrenal gland	Necrosis and infiltration of monocytes and lymphocytes	14	12, 13, 15
Thyroid gland	Destruction of follicular epithelial cells, several apoptotic cells	5	49
Testes	Germ cell destruction, apoptotic spermatogenetic cells	7	45
Heart	Edema and atrophy of myocardial fibers	22	12, 13, 15, 17