Blood glucose levels, body weight, and proteinuria in db/db and wild-type mice. Blood glucose levels (A) and body weight (B) were determined at monthly intervals in 2K wild-type mice (open triangles), 2K db/db mice (black triangles), and 1K db/db mice (nil: black squares, dashed line; vehicle: black squares; BL5923: open squares). Values represent means ± SEM.