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. 2007 Apr;170(4):1314–1324. doi: 10.2353/ajpath.2007.060340

Figure 7.

Figure 7

Microglial cell increase in mixed retinal cell cultures incubated in the presence of the PrP106-126 prion peptide. A and B: Microglial cell staining by the isolectin B4 lectin (ILB4) in control (A) and PrP106-126-treated retinal cell cultures (B). An increase in the number of microglia and a change of their morphology were observed after 4 days of treatment with PrP106-126. Control microglia were oval-shaped, showing no or a very few processes, whereas PrP106-126-treated microglial cells exhibited several cellular processes conferring a star-like morphology on the cell. C: Quantification of ILB4-labeled microglia in control retinal culture or culture treated with the PrP106-126 peptide. The difference in the number of microglial cells was statistically significant when applying the PrP106-126 prion peptide (*P < 0.05, SEM, n = 3). The scale bar in A represents 10 μm.