Figure 1.

The effect of Atrasentan/l-arginine therapy on I/R-induced microcirculatory disturbances and liver injury. a: Hepatic sinusoidal perfusion rates 2 hours, 6 hours, 24 hours, and 5 days after sham operation, I/R, and I/R with Atrasentan/l-arginine therapy (n = 4 each group). Hepatocellular damage measured 2 hours, 6 hours, 24 hours, and 5 days after I/R by plasma alanine aminotransferase (ALT) (b) and aspartate aminotransferase (AST) (c) levels (n = 8 each group). d: Tissue necrosis, quantified via morphometric analysis of clamped and nonclamped liver lobes at 5 days after clamping (n = 8 each group). ^#P < 0.05 versus sham; *P < 0.05 versus I/R.