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. 2007 Apr;170(4):1379–1388. doi: 10.2353/ajpath.2007.061028

Figure 4.

Figure 4

The effect of Atrasentan/l-arginine on the outgrowth of pre-established micrometastases. a: Tumor growth expressed as the HRA ratio, the relative increase in the percentage of liver tissue that has been replaced by tumor tissue in ischemic lobes compared with nonischemic lobes (n = 8 each group). #P < 0.05 versus sham; *P < 0.05 versus I/R. b: Microscopic appearance of I/R-accelerated outgrowth of micrometastases at 5 days after clamping, showing massive tumor (t) growth surrounding necrotic tissue areas (n). c: HIF-1α immunostaining in tumor tissue (t) from sham-operated mice and in clamped liver lobes. Arrows indicate HIF-1α-positive tumor cells at the tumor-necrosis (n) margin. Original magnifications: ×2 (b); ×20 (c).