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. 2007 Apr;170(4):1415–1427. doi: 10.2353/ajpath.2007.060728

Figure 2.

Figure 2

Accelerated rejection of cardiac allografts in vimentin-immunized mice. Kaplan-Meier survival graft shows accelerated rejection of 129/sv allografts placed in vim/CFA (Allo vim, n = 18) recipients compared with allografts placed in hel/CFA-immunized (Allo hel, n = 10) recipients (P < 0.0001, log-rank test). Isografts placed in vimentin-immunized C57BL/6 recipients (Syn vim) continued to beat at day 90. Vim/CFA mice were immunized with 400 μg of vimentin in 100 μl of CFA followed by a booster of 400 μg of vimentin alone without adjuvant. The hel/CFA controls received 200 μg of hel in 100 μl of CFA, followed by a booster of 200 μg of hel alone at 1 week. Recipients were transplanted 1 week after administration of booster antigen.