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AA is metabolized through three main pathways: the 5-LOX pathway (red line), the 15-LOX pathway (blue line), and the COX-2 pathway (green line). PGE2, LTA4, and LTB4 are the major inflammatory mediators produced in the COX-2 and 5-LOX pathways. A total of 24 feedback loops, which are involved in the network, make important contributions to the regulation of inflammatory mediators.
