Figure 3. Flux Analysis on the Three Main Pathways: The 5-LOX Pathway, the 15-LOX Pathway, and the COX-2 Pathway.

Four states were studied: the disease state with no addition of inhibitors (A), the inhibited state with addition of COX-2 inhibitor (B), addition of 5-LOX inhibitor (C), or addition of both COX-2 and 5-LOX inhibitors (D). Red line, 5-LOX pathway; blue line, 15-LOX pathway; and green line, COX-2 pathway.