Table 1.

Serum chemistry and coagulation analyses

Treatment	AST, units/liter	ALT, units/liter	BUN, mg/dl	CRE, mg/dl	PT, s	APTT, s	Fibrinogen, mg/dl
Acclimation	31 ± 6	38 ± 24	16 ± 6	0.8 ± 0.2	10.0 ± 0.2	18.7 ± 1.7	296 ± 63
D5W	33 ± 6	33 ± 8	15 ± 5	0.8 ± 0.1	11.0 ± 0.1	18.1 ± 1.1	286 ± 31
3 mg/kg	*	*	13 ± 3	0.7 ± 0.1	11.5 ± 1.2	21.3 ± 1.9	289 ± 77
9 mg/kg	41 ± 7	88 ± 71	12 ± 3	0.8 ± 0.1	10.4 ± 0.4	21.5 ± 2.5	230 ± 22
27 mg/kg	79 ± 26	90 ± 26	29 ± 9	4.0 ± 2.3	12.6 ± 3.6	23.3 ± 2.9	197 ± 11

Data were collected 24 h after each dose. PT, prothrombin time; APTT, activated partial thromboplastin time.

*At this dose level, one animal gave elevated levels that were not observed upon subsequent higher doses. Animal 1: AST = 27 units/liter, ALT = 24 units/liter; animal 2: AST = 39 units/liter, ALT = 55 units/liter; animal 3: AST = 534 units/liter, ALT = 600 units/liter.