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Chemical inhibition of prolyl 4-hydroxylase. (A) Chemical structures of α-ketoglutarate, a cofactor for prolyl 4-hydroxylase (Left), and two inhibitors of prolyl 4-hydroxylase activity that are related chemically to α-ketoglutarate (Center and Right). (B) Effect of prolyl 4-hydroxylase inhibitors on wild-type C. elegans and dpy-18 and phy-2 homozygotes. a, Only dead embryos; b, dead embryos and dead larvae.
