Table 2.
Incidence of tumors induced by multiple low NMBA doses in Fhit +/+ and +/− mice
| Wk post-treatment | Fraction of tumor-bearing animals
|
|||||
|---|---|---|---|---|---|---|
| Fhit | Esoph* | Fst | SCJ | Seb | Tumor-bearing mice | |
| 6 | +/+ | 1/10 | 1/10 | 0/10 | ND | 2/10 |
| 6 | +/− | 0/10† | 5/10 | 4/10 | ND | 7/10 |
| P = 1.0 | P = 0.14 | P = 0.09 | P = 0.07 | |||
| 10 | +/+ | 0/8 | 1/8 | 1/8 | 0/8 | 2/8 |
| 10 | +/− | 2/12 | 10/12 | 5/12 | 7/12 | 12/12 |
| P = 0.49 | P = .005 | P = 0.32 | P = 0.015 | P = 0.0007 | ||
*
Number of mice with tumors/respective number of mice.
† One esophagus showed dysplasia. The tumors at 6 wk were mainly squamous papillomas. The tumors at 10 wk in the +/− mice were mostly squamous papillomas, but two Fhit +/− mice had squamous carcinomas of the forestomach or junction; one Fhit +/+ and one +/− mouse at 10 wk showed a small adenoma of the forestomach. ND, not detected.