Figure 1.

Organization of the leukocyte receptor complex on human chromosome 19q13.4. Two contigs were deduced from PACs positive with combinations of individual probes. The complete sequences of PACs 1060P11² and 52N12¹ are displayed in Figs. 2 and 4, respectively. A sequence of a section of the KIRs from a haplotype similar to that of 72N6¹ is available (GenBank database accession no. AC011501). The KIR gene family is flanked by the ILT cluster I and the FcαR gene. The numbers of KIR genes differ depending on the haplotype. The ILT genes are grouped in two clusters separated by the LAIR genes. A link between the two clusters remains to be established. Marker 204 is based on a PCR product designed for other sequences in the database. Although all PAC sizes are to scale, distances between genes outside the sequenced region are approximate. At the telomeric end, the gene designated X is not related structurally to the Ig-like receptors. 52N12¹ and 72N6¹ represent one haplotype, and the contig containing 167B21² is part of the second haplotype. This was based on sequence polymorphism in the PCR-amplified ILT3 gene and other differences. Arrows point 5′ to 3′.