Figure 1.

Induction of CTL against hTRT in PBMC from normal blood donors. T cells from HLA-A2⁺ individuals were stimulated by autologous PBMC pulsed with hTRT-derived synthetic peptides as detailed in Materials and Methods. (A) Results refer to effector cells from individual donors immunized in vitro against p540. (○) T2 cells and (●) T2 cells pulsed with p540 as targets. (B) Results refer to effector cells from individual donors immunized in vitro against p865. (⋄) T2 cells and (♦) T2 cells pulsed with p865 as targets. Effector-to-target ratios are indicated on an individual basis. Percent cytotoxicity was calculated as specified in Materials and Methods.