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CTL of prostate cancer patient against hTRT are MHC Class I restricted. CTL lines 380.540.1 and 380.865.1 of a patient (no. 380) were tested in a 51Cr-labeled release assay by using as targets T2 cells pulsed with p540 (A) or p865 (B). The following inhibitory antibodies were used: murine monoclonal antibody BB7.2 (IgG2b) against MHC Class I, murine monoclonal antibody Q5/13 (IgG2a) against HLA-DR, and the engineered antibody γ1RGD3 that blocks NK cell function.
