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. 2000 Apr 11;97(9):4802–4807. doi: 10.1073/pnas.090065597

Figure 3.

Figure 3

In vivo assay for activity of ADV.mEnd-expressed endostatin. An adenovirus expressing hVEGF165 was injected s.c. into nude mice. At the same time, ADV.mEnd or control vector (ADV.DL312) was administered through the tail vein. After 14 days, the animals were killed, and the ADV.hVEGF165 injection site was histologically analyzed. ICAM-1 staining shows no s.c. blood vessels in the ADV.mEnd-treated animals (A) but showed increased angiogenesis in the ADV.DL312-treated animals (B). (×100.)