Figure 4.

Delay of tumor engrafting by ADV.mEnd. Recombinant adenovirus was injected i.v. 2 days before s.c. implantation of 1 × 10⁵ JC cells. At 12 days after tumor implantation, a statistically significant difference in tumor size (P = 0.01) between the ADV.mEnd-treated (□) and the control vector-treated (ADV.DL312, ●) groups was observed. Tumor volume reduction at day 28 was 60% for the treatment group vs. controls (P = 0.0008). ∗, Statistically significant at the P = 0.01 level by unpaired Student's t test. Overall index of tumor size, median ATTV: ADV.mEnd, 88 mm³; ADV.DL312, 190 mm³. P = 0.003 (Wilcoxon rank sum test). There were 20 mice per group. Bars indicate ± SEM.