Table 1.
Results in Dogs Given DLA-Identical Littermate Marrow Grafts after Conditioning⁎
| TBI Dose (Gy) | Pretransplantation Immunomodulation | Posttransplantation Immunosuppression | Sustained Engraftment (%) | Median Time of Rejection (Weeks) | P Value | References |
|---|---|---|---|---|---|---|
| 2 | None | MMF + CSP | 11/12 (92) | 12 | .0373 | [1] |
| 2 | None | SRL + CSP | 6/7 (86) | 11 | [2] | |
| 1 | None | MMF + CSP | 0/6 (0) | 10 | .0014 | [1] |
| 1 | None | SRL + CSP | 0/5 (0) | 9 | [2] | |
| 1 | ATG | MMF + CSP | 1/5 (20) | 9.5 | .145 | [13] |
| 1 | MTX + donor PBMCs | MMF + CSP | 2/6 (33) | 8 | .315 | [25] |
| 1 | CTLA4-Ig + donor PBMCs | MMF + CSP | 4/6 (66) | 14 | .721 | [3] |
⁎
Conditioning consisted of either 1 or 2 Gy of TBI and posttransplantation immunosuppression with CSP combined with MMF or sirolimus (SRL). The P values refer to comparisons of current results with those in previous studies using the log-rank test.