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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Bioorg Med Chem. 2006 Dec 13;15(5):2147–2155. doi: 10.1016/j.bmc.2006.12.016

Table 1.

Inhibitory properties of compound 2 in pineal cells.

Treatment Melatonin production (pmol/105 cells) AANAT Activity (nmol/h/105 cells)
Control (N=6) 0.3 ± 0.05 not detected
NE (N=6)1 11.8 ± 1.25 1.2 ± 0.08
NE + 2 (10 μM, ,N=6) 9.0 ± 1.39 2.2 ± 0.12*
NE + 2 (50 μM, N=3) 5.7 ± 0.18* 1.6 ± 0.04*
1

Cells were treated with 2 for 1.5 hours and then norepinephrine (NE) was added for the last 6 hours of culture. Significantly different from NE treatment group,

*

P<0.05.