Table 1.
Changes in muscle protein content following bi-daily injection of either 10 μg of clenbuterol kg-1 or saline only.
| Muscle protein content (mg) | |||
|---|---|---|---|
| Day 0 | Heart | Soleus | Tibialis anterior |
| Control | 149 ± 8.2 | 24.0 ± 2.8 | 98.6 ± 7.6 |
| Day 8 | |||
| Control | 157.2 ± 11.2 | 24.0 ± 2.4 | 113.0 ± 10.4 |
| 10 μg clenbuterol | 153. 2 ± 10.8 | 24.4 ± 2.2 | 111.0 ± 13.4 |
| % change | -2.5 | +1.6 | -1.8 |
| Day 16 | |||
| Control | 170.8 ± 10.6 | 27.0 ± 3.6 | 111.6 ± 8.0 |
| 10 μg clenbuterol | 166.8 ± 9.2 | 26.2 ± 2.8 | 122.6 ± 6.4* |
| % change | -2.3 | -3.0 | +9.8 |
| Day 32 | |||
| Control | 168.2 ± 12.4 | 30.0 ± 2.4 | 130.4 ± 7.0 |
| 10 μg clenbuterol | 185.8 ±14.0* | 29.2 ± 2.2 | 129.4 ± 11.8 |
| % change | +10.5 | -2.7 | -0.8 |
Data are presented as mean ± SD, (n = 5, in each group). One-way analysis of variance revealed that the protein content of all the muscles from saline-treated animals increased significantly (P<0.05) over the 32-day period. % change represents the difference between muscles exposed to clenbuterol or saline at each time point investigated.
*
Tukey HSD post-hoc analyses showed that administration of clenbuterol induced a significant (P<0.05) increase in the muscle protein content above that seen in the control (saline only) muscles.