Table 1.

Pharmacokinetic parameters (median (range)) in plasma following flunixin meglumine (2.2 mg/kg) given intravenously, intramuscularly and orally to 6 Norwegian dairy goats.

		Route of administration
parameter	unit	i.v. (n = 6)		i.m. (n = 6)		p.o. (n = 6)
AUC	h/μg/ml	21	(14–36)	16	(14–19)	12	(7.5–17)
CL	ml/h/kg	110	(60–160)	-		-
Vdss	l/kg	0.35	(0.23–0.41)	-		-
λ	l/h	0.19	(0.14–0.35)	0.20	(0.10–0.27)	0.16	(0.12–0.20)
Vdλ	l/kg	0.5	(0.4–0.8)	-		-
MRT	h	3.1	(2.1–5.9)	4.2	(3.5–4.5)	7.7	(6.0–9.3)
t1/2	h	3.6	(2.0–5.1)	3.4	(2.6–7.1)	4.2	(3.4–6.0)
Cmax1	μg/ml	-		6.1	(3.3–7.4)	1.2	(0.8–2.0)
Cmax2	μg/ml	-		-		1.3	(0.8–1.8)
Tmax1	h	-		0.37	(0.25–0.75)	0.37	(0.25–1.0)
Tmax2	h	-		-		3.5	(2.5–5)
F	%	-		79	(53–112)	58	(35–120)

AUC = area under the concentration time curve extrapolated to infinity, CL = total body clearance, Vd_ss = apparent volume of distribution at steady state, λ = elimination rate constant, Vd_λ = volume of distribution based on the terminal phase, MRT = mean residence time, t1/2 = half-life of the terminal phase, C_max = maximum concentration, T_max = time for C_max, F = bioavailability.