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Loss of TGF-β-dependent transcriptional activation by MH1 domain mutants of Smad2 and Smad4. (A) Location of the MH1-domain arginine mutations in Smad2 and Smad4. (B and C) HepG2 cells, transfected with A3-Lux reporter alone or with FAST1 and wild-type (wt) or mutant (m) Smad2 or Smad4, were treated with or without TGF-β. Luciferase activity is expressed as the mean ± SD of triplicates from representative experiments.
