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. 2007 Feb 2;92(8):2944–2952. doi: 10.1529/biophysj.106.092981

FIGURE 3.

FIGURE 3

Movements of mitochondria are differentially influenced by ATP and ADP. (A) Hypoxia and ATP. The trajectories of mitochondria in dendrites were repositioned to begin at the same point for comparison. Note that inhibition of mobility by hypoxia was not reversed after injection of 0.4 mM ATP. (B) ATP (0.4 mM) reverses hypoxic activation of ATP-sensitive K+ (KATP) channels. Mean open probabilities of the channels (Popen) are indicated near each trace. (C) ADP and hypoxia. Note that after suppression of mitochondrial movements by injection of 0.4 mM ADP, hypoxia produced no effect. All presented trajectories were obtained by applying SPT to the 3-min-long recordings of mitochondrial movements in the control and after the treatments. Note decreases in the lengths of continuous directed movements of mitochondria during hypoxia and at elevated [ADP]i levels.