Skip to main content
. 2000 Apr 25;97(9):4826–4831. doi: 10.1073/pnas.97.9.4826

Figure 1.

Figure 1

Survival of mice expressing Ro1 in the heart: Kaplan–Meier survival plot of adult mice expressing Ro1. Doxycycline was withdrawn from 15 αMHC-tTA/tetO-Ro1 mice to induce Ro1 expression. All αMHC-tTA/tetO-Ro1 mice survived maximal induction of Ro1 (7–10 days). More than 40% of the mice died after 8 wk of Ro1 expression and 90% after 16 wk. Reinitiation (arrow) of doxycycline at 8 wk prevented further mortality in another group of αMHC-tTA/tetO-Ro1 mice (n = 15). None of the control mice died (αMHC-tTA/tetO-Ro1 on doxycycline for 16 wk, n = 20).