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. 2000 Apr 25;97(9):4826–4831. doi: 10.1073/pnas.97.9.4826

Figure 2.

Figure 2

PTX reveals Gi-induced ventricular conduction delay and drug-induced signaling via expression of Ro1. Administration of PTX reduced ECG abnormalities in mice expressing Ro1. (A) Sinus rhythm (heart rate, 600 beats per min) with narrow QRS complex (<15 ms) before Ro1 expression. (B) Irregular rhythm with widened QRS complex (>25 ms) after 20 days of Ro1 expression. (C) Irregular rhythm with widened QRS maintained for 48 h before PTX injection. (D) Sinus rhythm (heart rate, 600 beats per min) with narrow QRS complex (<15 ms) 24 h after PTX injection.