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Activation of ionic currents in MDM by gp120 and by chemokines. Patch clamp recordings were carried out on MDM stimulated with gp120 (200 nM) from HIV-1 JRFL (A) and IIIB (B). Incubation of gp120 with anti-Env antiserum blocked current activation but did not prevent subsequent activation by non-neutralized gp120 (C and D). MDM were also stimulated with the chemokines (1 μg/ml) MIP-1β (E) and SDF-1α (F).
