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CCR5 and CXCR4 dependence of MDM ion current activation by gp120. Incubation of MDM from CCR5 wild-type donors (WT) with the CXCR4 inhibitor AMD3100 (5 μg/ml) blocked currents elicited by IIIB gp120 but did not inhibit responses to JRFL or MIP-1β (A and B). In MDM from donors homozygous for the CCR5 Δ32 allele, no current was evoked by JRFL gp120 whereas both IIIB and SDF-1α elicited ion currents (C and D).
