TABLE 1.
Comparison of intrinsic membrane and firing properties in layer 1 cells from transgenic (n = 13) vs. wild-type (n = 130) mice
Parameter | Animal | Mean ± SD | P Value |
---|---|---|---|
ERest, mV | GAD-GFP | -63.4 ± 2.63 | 0.0710 |
Wild type | -61.7 ± 5.76 | ||
τmem, ms | GAD-GFP | 10.9 ± 4.86 | 0.8624 |
Wild type | 11.2 ± 5.30 | ||
RUI, Gω | GAD-GFP | 0.186 ± 0.0667 | 0.5492 |
Wild type | 0.163 ± 0.135 | ||
I-VSlope ratio | GAD-GFP | 1.09 ± 0.0877 | 0.5528 |
Wild type | 1.10 ± 0.0864 | ||
VThresh, mV | GAD-GFP | 27.2 ± 1.41 | 0.8224 |
Wild type | 26.4 ± 2.16 | ||
I-FSlope, spk/pA | GAD-GFP | 0.334 ± 0.156 | 0.3338 |
Wild type | 0.291 ± 0.151 | ||
ISIRatio | GAD-GFP | 0.554 ± 0.306 | 0.4506 |
Wild type | 0.641 ± 0.399 | ||
IHW,spk, ms | GAD-GFP | 0.703 ± 0.175 | 0.3011 |
Wild type | 0.780 ± 0.261 | ||
ASpl, mV | GAD-GFP | 58.2 ± 12.7 | 0.1284 |
Wild type | 63.5 ± 11.7 | ||
tpk,AHP | GAD-GFP | 0.149 ± 0.138 | 0.5938 |
Wild type | 0.164 ± 0.0905 | ||
AAHP, mV | GAD-GFP | 12.5 ± 2.03 | 0.02617 |
Wild type | 10.6 ± 2.89 |
Parameter values were compared using unpaired Student’s t-tests, with a significance level of 0.005 to correct for multiple comparisons.