S/C ratios for antibody responses to HHV8 lytic ORF65 and latent ORF73 antigens in HIV-infected and uninfected homosexual men (A), in HIV-infected men without KS according to five CD4 categories (401–500, 301–400, 201–300, 101–200, and 1–100 cells/mm3), and in HIV-infected men with KS before and after KS was diagnosed [ORF65 (B) and ORF73 (C)]. Of 71 patients with KS, 69 had samples taken before and after KS was diagnosed. Of these, 41 and 44 tested positive for antibodies against ORF65 before and after KS was diagnosed, respectively (B); 36 and 33 tested positive for antibodies against ORF73 before and after KS was diagnosed, respectively (C).