Cost and utility variables, discount rate, and transition probabilities used in statistical model

Variable	Minimum	Likeliest	Maximum
Cost variables (£)*
Cost of procedure:
MIDCAB	2832.27	3146.97	3461.67
PTCS	1743.40	1937.11	2130.82
Cost of follow-up:
MIDCAB	454.66	505.18	555.70
PTCS	427.06	474.51	521.96
Cost of myocardial infarction	407.82	453.13	498.44
Cost of stroke	1427.40	1586.00	1744.60
Travel expenses:
MIDCAB	1.98	2.20	2.42
PTCS	2.48	2.76	3.04
Out of pocket expenses for patient:
MIDCAB	4.34	4.82	5.30
PTCS	4.91	5.46	6.01
Cost to society for time off work:
Patient
MIDCAB	1348.29	1498.10	1647.91
PTCS	1084.14	1204.60	1325.06
Carer
MIDCAB	29.12	32.36	35.60
PTCS	37.07	41.19	45.31
Utility variables (QALYs)†
Asymptomatic utility	0.774	0.860	0.946
Utility of MIDCAB	0.745	0.828	0.910
Utility of PTCS	0.772	0.857	0.943
Utility of myocardial infarction	0.752	0.835	0.919
Utility after stroke	0.504	0.560	0.616
Utility of MIDCAB after stroke	0.475	0.528	0.580
Utility of PTCS after stroke	0.502	0.557	0.613
Utility of myocardial infarction after stroke	0.482	0.535	0.589
Utility after second stroke	0.477	0.530	0.583
Discount rate‡	0	0.035	0.06
Transition probabilities§
Probability of repeat revascularisation with PTCS:
MIDCAB	0.0082	0.0174	0.0452
PTCS	0.0227	0.0583	0.1135
Probability of repeat revascularisation with CABG:
MIDCAB	0.0016	0.0073	0.0121
PTCS	0.0057	0.0094	0.0400
Rate of myocardial infarction:
MIDCAB	0.0083	0.0170	0.0419
PTCS	0.0096	0.0240	0.0482
Rate of stroke:
MIDCAB	0.0018	0.0044	0.0105
PTCS	0.0080	0.0192	0.0462
Perioperative mortality:
MIDCAB	0.0026	0.0224	0.0281
PTCS	0.0059	0.0075	0.0610
Mortality†:
Myocardial infarction	0.2	0.25	0.5
Stroke	0.1	0.2	0.3
Baseline¶

£1.00 (€1.51; $1.96). MIDCAB=minimally invasive direct coronary artery bypass; PTCS=percutaneous transluminal coronary artery stenting; CABG=coronary artery bypass grafting.

Distributions for each variable were triangular.

*Reeves et al.¹⁷

†NICE.¹³

‡NICE.¹⁰

§Aziz et al.⁴

¶UK government actuary's department tables.¹²