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Model for the two-step genesis of the complex rearrangement observed in the supernumerary der(22)t(8;22) proband’s father. A germline inversion of a 22q11.2 region flanked by breakpoints in LCRs A and D occurred before a t(8;22) translocation, the breakpoints of which are located at the center of palindromic sequences at the recurrent LCR-B site (open arrows) and an AT-rich locus of 8q24.13 (solid arrows).
